Dosing Scenario (Table 2, July 2025 PI)

Initiation 0 → 80 mg BID Initiation 0 → 120 mg BID Escalation 80 → 120 mg BID Escalation 120 → 160 mg BID

160 mg BID is only achievable via escalation from 120 mg — there is no direct 0→160 mg loading column in the July 2025 PI.

IV Infusion Start Date & Time

Scheduled IV Start (optional)

Enter date and time to generate a complete dose administration schedule with exact timestamps for each dose and QTc monitoring window. Leave blank to view relative timing only.

⚠ Contraindications — Verify Before Proceeding
Sotalol IV is contraindicated if: baseline QTc > 450 ms · Serum K⁺ < 4.0 mEq/L · Serum Mg²⁺ not normalized · Sinus bradycardia (<50 bpm), sick sinus syndrome, or 2nd/3rd° AV block without pacemaker · Congenital or acquired long QT syndrome · Cardiogenic shock / decompensated HF · Bronchial asthma.

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CrCl (Cockcroft-Gault)
mL/min · dose selection

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eGFR_{CKD-EPI 2021}
mL/min/1.73m² (reference)

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GFRᵢ = (eGFR/1.73)×BSA
mL/min (reference)

Recommended IV Loading Dose · Infuse over 1 hour

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1 hr

Infusion
Duration

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Min. delay to first oral dose
after infusion end

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Oral dosing
interval

📡 QTc Monitoring Protocol (PI Section 2.3)

Monitor QTc every 15 minutes during the 1-hour infusion.
Check QTc at peak (2–4 h post-dose) after the first oral dose in all patients.
Check QTc at peak after the second oral dose in patients with CrCl ≥ 60 mL/min.
If QTc prolongs to >500 ms, or increases ≥20% from baseline on 80 mg initiation → discontinue.
If QTc prolongs to >500 ms on 120 mg initiation → discontinue and consider 80 mg.
Ensure serum K⁺ ≥ 4.0 mEq/L and Mg²⁺ normalized before and throughout therapy.

Sotalol IV Loading Calculator